Adaptations of 'Alice's Adventures in Wonderland'

This English Literature undergraduate dissertation will analyse three adaptations of Alice’s Adventures in Wonderland to explore how different mediums can translate key components of the original text to ensure that they are still recognisably Alice. From this, the work will then determine why Alice’s Adventures in Wonderland continues to be adapted. The three adaptations chosen to do this are: Tim Burton’s film Alice in Wonderland, Jeff Noon’s book Automated Alice and Christopher Wheeldon’s Ballet Alice’s Adventures in Wonderland, all of which will be analysed against Lewis Carroll’s Alice’s Adventures in Wonderland. Three key themes of Alice’s Adventures in Wonderland have been chosen to explore how the adaptations display Alice, but also their own creativity. These themes are playfulness, Alice’s characterisation and madness. Adaptation theory will be the main theory used throughout, however other relevant secondary criticism will also be introduced when appropriate. The conclusion will surmise how, due to the width and depth of the themes in the original, adaptors return to Alice’s Adventures in Wonderland due to the scope for creativity and desire for resolution that can be found in it. It will also state how Lewis Carroll’s own personal feelings towards young girls creates conflict in the story, i.e. the necessity of growing up versus the desire for this not to occur. Furthermore, it will show how the themes discussed argue the delight of childhood and the need for childishness in the formation of Wonderland and the character of Alice to prolong his attachment to Alice Liddel

Anger displays and integrative behavior among work dyads in teams:A regulatory fit approach

Anger has often been portrayed as a destructive social emotion in the literature. However, research conducted with a social functional approach has also revealed the functionality of anger and called for a shift toward understanding the conditions in which anger can have interpersonal utility at work. Given the complicated role and inevitability of anger in work teams, it is important to understand when team members can reap the interpersonal utility of anger and promote adaptive social interactions. Contributing to this approach, we developed a contingency model to postulate when and why anger displays can produce integrative behavior among co-worker dyads in teams. Drawing on regulatory fit theory we conducted three studies (one laboratory study and two field studies with a round-robin design) to examine our hypotheses. Results indicated that co-workers' anger displays were positively related to focal workers' (targets of anger) integrative behavior toward angry co-workers (expressers) when targets had a high level of prevention focus and perceived a low level of team goal interdependence. As expected, moreover, targets' problem identification with expressers was found to be the mechanism of this conditional relationship. Implications of our research are discussed

Testing isosource : stable isotope analysis of a tropical fishery with diverse organic matter sources

Author Posting. © Ecological Society of America, 2006. This article is posted here by permission of Ecological Society of America for personal use, not for redistribution. The definitive version was published in Ecology 87 (2006): 326–333, doi:10.1890/05-0721.We sampled consumers and organic matter sources (mangrove litter, freshwater swamp-forest litter, seagrasses, seagrass epiphytes, and marine particulate organic matter [MPOM]) from four estuaries on Kosrae, Federated States of Micronesia for stable isotope (δ13C and δ34S) analysis. Unique mixing solutions cannot be calculated in a dual-isotope, five-endmember scenario, so we tested IsoSource, a recently developed statistical procedure that calculates ranges in source contributions (i.e., minimum and maximum possible). Relatively high minimum contributions indicate significant sources, while low maxima indicate otherwise. Litter from the two forest types was isotopically distinguishable but had low average minimum contributions (0–8% for mangrove litter and 0% for swamp-forest litter among estuaries). Minimum contribution of MPOM was also low, averaging 0–13% among estuaries. Instead, local marine sources dominated contributions to consumers. Minimum contributions of seagrasses averaged 8–47% among estuaries (range 0–88% among species). Minimum contributions of seagrass epiphytes averaged 5–27% among estuaries (range 0–69% among species). IsoSource enabled inclusion of five organic matter sources in our dual-isotope analysis, ranking trophic importance as follows: seagrasses > seagrass epiphytes > MPOM > mangrove forest > freshwater swamp-forest. IsoSource is thus a useful step toward understanding which of multiple organic matter sources support food webs; more detailed work is necessary to identify unique solutions.This research was funded through a research joint venture agreement between the USDA and CMP at the University of Georgia

"Women's rights, the European Court and Supranational Constitutionalism"

This analysis examines supranational constitutionalism in the European Union. In particular, the study focuses on the role of the European Court of Justice in the creation of women’s rights. I examine the interaction between the Court and member state governments in legal integration, and also the integral role that women’s advocates – both individual activists and groups – have played in the development of EU social provisions. The findings suggest that this litigation dynamic can have the effect of fueling the integration process by creating new rights that may empower social actors and EU organizations, with the ultimate effect of diminishing member state government control over the scope and direction of EU law. This study focuses specifically on gender equality law, yet provides a general framework for examining the case law in subsequent legal domains, with the purpose of providing a more nuanced understanding of supranational governance and constitutionalism

Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.

Genetic screens in simple model organisms have identified many of the key components of the conserved signal transduction pathways that are oncogenic when misregulated. Here, we identify H37N21.1 as a gene that regulates vulval induction in let-60(n1046gf), a strain with a gain-of-function mutation in the Caenorhabditis elegans Ras orthologue, and show that somatic deletion of Nrbp1, the mouse orthologue of this gene, results in an intestinal progenitor cell phenotype that leads to profound changes in the proliferation and differentiation of all intestinal cell lineages. We show that Nrbp1 interacts with key components of the ubiquitination machinery and that loss of Nrbp1 in the intestine results in the accumulation of Sall4, a key mediator of stem cell fate, and of Tsc22d2. We also reveal that somatic loss of Nrbp1 results in tumourigenesis, with haematological and intestinal tumours predominating, and that nuclear receptor binding protein 1 (NRBP1) is downregulated in a range of human tumours, where low expression correlates with a poor prognosis. Thus NRBP1 is a conserved regulator of cell fate, that plays an important role in tumour suppression

Improving Benefit-harm Assessment of Therapies from the Patient Perspective: OMERACT Premeeting Toward Consensus on Core Sets for Randomized Controlled Trials

Objective: Outcome Measures in Rheumatology (OMERACT) convened a premeeting in 2018 to bring together patients, regulators, researchers, clinicians, and consumers to build upon previous OMERACT drug safety work, with patients fully engaged throughout all phases. Methods: Day 1 included a brief introduction to the history of OMERACT and methodology, and an overview of current efforts within and outside OMERACT to identify patient-reported medication safety concerns. On Day 2, two working groups presented results; after each, breakout groups were assembled to discuss findings. Results: Five themes pertaining to drug safety measurement emerged. Conclusion: Current approaches have failed to include data from the patient’s perspective. A better understanding of how individuals with rheumatic diseases view potential benefits and harms of therapies is essential

Randomised controlled trial to improve health and reduce substance use in established psychosis (IMPaCT): cost-effectiveness of integrated psychosocial health promotion

Background: There is mounting evidence that people with severe mental illness have unhealthy lifestyles, high rates of cardiovascular and metabolic diseases, and greater risk of early mortality. This study aimed to assess the cost-effectiveness of a health promotion intervention seeking to improve physical health and reduce substance use in people with psychosis. Methods: Participants with a psychotic disorder, aged 18-65 years old and registered on an enhanced care approach programme or equivalent were recruited from community mental health teams in six mental health trusts in England. Participants were randomisation to either standard community mental health team care (treatment as usual) or treatment as usual with an integrated health promotion intervention (IMPaCT). Cost-effectiveness and cost-utility analyses from health and social care and societal perspectives were conducted alongside a cluster randomised controlled trial. Total health and social care costs and total societal costs at 12 and 15 months were calculated as well as cost-effectiveness (incremental cost-effectiveness ratios and cost-effectiveness acceptability curves) at 15 months based on quality of life (SF-36 mental and physical health components, primary outcome measures) and quality adjusted life years (QALYs) using two measures, EQ-5D-3 L and SF-36. Data were analysed using bootstrapped regressions with covariates for relevant baseline variables. Results: At 12-15 months 301 participants had full data needed to be included in the economic evaluation. There were no differences in adjusted health and social care costs (£95, 95% CI -£1410 to £1599) or societal costs (£675, 95% CI -£1039 to £2388) between the intervention and control arms. Similarly, there were no differences between the groups in the SF-36 mental component (−0.80, 95% CI -3.66 to 2.06), SF-36 physical component (−0.68, 95% CI -3.01 to 1.65), QALYs estimated from the SF-36 (−0.00, −0.01 to 0.00) or QALYs estimated from the EQ-5D-3 L (0.00, 95% CI -0.01 to 0.02). Cost-effectiveness acceptability curves for all four outcomes and from both cost perspectives indicate that the probability of the health promotion intervention being cost-effective does not exceed 0.4 for willingness to pay thresholds ranging from £0-£50,000. Conclusions: Alongside no evidence of additional quality of life/clinical benefit, there is also no evidence of cost-effectiveness

Stiffness Is the Cardinal Symptom of Inflammatory Musculoskeletal Diseases, Yet Still Variably Measured: Report from the OMERACT 2016 Stiffness Special Interest Group

Objective: The objectives of the Outcome Measures in Rheumatology (OMERACT) Stiffness special interest group (SIG) are to characterize stiffness as an outcome in rheumatic disease and to identify and validate a stiffness patient-reported outcome (PRO) in rheumatology. Methods: At OMERACT 2016, international groups presented and discussed results of several concurrent research projects on stiffness: a literature review of rheumatoid arthritis (RA) stiffness PRO measures, a qualitative investigation into the RA and polymyalgia rheumatica patient perspective of stiffness, data-driven stiffness conceptual model development, development and testing of an RA stiffness PRO measure, and a quantitative work testing stiffness items in patients with RA and psoriatic arthritis. Results: The literature review identified 52 individual stiffness PRO measures assessing morning or early morning stiffness severity/intensity or duration. Items were heterogeneous, had little or inconsistent psychometric property evidence, and did not appear to have been developed according to the PRO development guidelines. A poor match between current stiffness PRO and the conceptual model identifying the RA patient experience of stiffness was identified, highlighting a major flaw in PRO selection according to the OMERACT filter 2.0. Conclusion: Discussions within the Stiffness SIG highlighted the importance of further research on stiffness and defined a research agenda

(Re)visitando a la madre (des)naturalizada : búsquedas y encuentros entre personas adoptadas en Chile y sus madres de origen

Este artículo es resultado de los proyectos FONDECYT N°3170338 "Adopciones en Chile: la construcción de narrativas sobre los orígenes y la identidad", REDI170133 "Investigación Interdisciplinaria sobre Políticas Reproductivas y Parentales", Programa Coope-ración Internacional (PCI), ambos financiados por la Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) de Chile; y del Proyecto I+D CSO2015-64551-C3-1-R "Del control de la natalidad a la ansiedad demográfica: comunicación, secreto y anonimato en las tecnologías reproductivas del siglo XXI", MINECO/FEDER.En este artículo se presentan algunos resultados de una investigación cualitativa que explora y analiza las narrativas de un grupo de personas adultas que fueron adoptadas en Chile, que han buscado sus orígenes y que han establecido contacto con sus madres de origen. En sus narrativas, las personas entrevistadas adhieren, tensionan y/o desafían los principios y discursos que conforman las políticas y prácticas adoptivas hegemónicas, resignificando de formas diversas su experiencia de adopción en el proceso de (re)construcción de sus identidades y de reorganización de sus relaciones de parentesco. Se discuten las tensiones y ambivalencias que se juegan en los procesos de búsquedas de orígenes y los desafíos asociados.This paper presents some results of a qualitative research that explores and analyzes the narratives of a group of adults who were adopted in Chile, and who have searched for their origins and made contact with their birth mothers. In their narratives, the people interviewed adhere to, strain, and/or challenge the principles and discourses that make up hegemonic adoption policies and practices, resignifying their experience of adoption in various ways, as they (re)build their identities and reorganize their kinship relationships. It discusses the tensions and ambivalences that play out in the search for origins and the challenges associated with it